Post-Op Px^®

Post-Op Px^® is a unique prognostic test, designed to provide patients and their physicians with more information as they make decisions about treatment options. Post-Op Px assesses patients as high or low risk for PSA recurrence as well as serious disease progression.

Post-Op Px endpoints predict:

• PSA Recurrence: a biochemical recurrence within five years after surgery
• Disease Progression: evidence of bone/soft tissue metastasis, progression through hormonal therapy) within five years after surgery

Post-Op Px utilizes a patented systems pathology approach to analyze prostatectomy tissue by combining cellular, molecular and clinical information to provide a thorough and more accurate reflection of each patient’s individual risk. Aureon’s Post-Op Px is based on data from a cohort of 758 patients and is supported by peer-reviewed research papers in the Journal of Clinical Oncology and the Journal of Clinical Investigation. In addition, Aureon recently presented new clinical information on Post-Op Px at the International Robotic Urology Symposium (IRUS).

Post-Op Px benefits post-prostatectomy patients by:

• More accurately predicting disease progression post-prostatectomy, compared to histology-based high-risk features such as extracapsular extension, or positive surgical margins
• Identifying patients who are at high risk for disease progression and who may benefit from early adjuvant therapies
• Helping alleviate patient anxiety caused by high risk, post-surgical features (e.g. positive surgical margins)
• Assisting with patient selection for future randomized clinical trials

Comparison:  Post-Op Px vs. Surgical Margins (SM)

In a head-to-head comparison of patients who had surgery (as illustrated in the above Kaplan-Meier curve), Post-Op Px more accurately stratifies patients as low or high risk for disease progression than Surgical Margins (SM).

Comparison:  Post-Op Px vs. Extracapsular Extension (ECE)

In a head-to-head comparison of patients who had surgery (as illustrated in the above Kaplan-Meier curve), Post-Op Px more accurately stratifies patients as low or high risk for disease progression than Extracapsular Extension (ECE). 

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